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In 1874, Fanny Angelina married physician and bacteriologist Walther Hesse, an investigator of air quality and, specifically, air-borne microbes. In the Winter of 1880-81, Hesse became a research student with Koch in Berlin and experienced firsthand the difficulty of growing microbes on gelatine and the other growth media used at the time.
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Moving beyond just black and white towards full-colour variable palettes presents another set of problems. Taking the methods presented above and quantising an image using an arbitrary colour palette reveals that error-diffusion is also better at preserving colour information when compared to ordered dithering.
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